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A study conducted on pregnant mice, the species with a very similar biological and behavioral makeup to humans, also found that B12 deficiency led to high cholesterol levels and a significant increase in body fat percentage in pregnant mice

Beginners should start with 50mg daily for the first 1-2 weeks to assess tolerance, then progress to the standard dose of 75mg daily for weeks 3-8

Microb Pathog 199:107244 Ivashkin V, Poluektov Y, Kogan E, Shifrin O, Sheptulin A, Kovaleva A et al (2021) Disruption of the pro-inflammatory, anti-inflammatory cytokines and tight junction proteins expression, associated with changes of the composition of the gut microbiota in patients with irritable bowel syndrome

Targeted treatments seem to block such pathways slightly