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Insight: As Torrent Pharmaceuticals noted, to truly disrupt the entire market, GLP-1s must eventually bridge the massive price gap with existing oral gliptins, which currently cost just ~10 per tablet

Semaglutide is not primarily eliminated by the kidneys

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For researchers whose side effects are dose-dependent and peak-related, this can make a dramatic difference in tolerability

But for Lurie, the argument that demand should inevitably lead to a stamp of approval falls short given the "extremely thin science." "If at the end of the day these products are approved, I see nothing good coming out of it," he said

Women and kidney disease: Reflections on World Kidney Day 2018