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In: Bailey LB, ed

That could be why so many of us often feel like we're not at our best

Because HepG2 cells are highly de-differentiated compared to normal hepatocytes in situ, and therefore are expected to have a less robust Met cycle and transsulfuration pathway than those found in normal liver, the GSH pool in normal liver could contain a substantially larger proportion of Met-derived S [115, 116, 118120]

Relative Precaution To make this clearer, our team put together a simple table to distinguish between a hard 'no' and a 'proceed with extreme caution' scenario

Several profiles tend to respond well: Adults over 45 whose natural glutathione synthesis declines with age, since aging reduces the enzymes responsible for production

doi: 10.1038/ng.764 [DOI] [PMC free article] [PubMed] [Google Scholar] 61