Figure 5 Systemic inflammation Systemic inflammation (225) and neuroinflammation (4547) are thought to play a major role in ME/CFS
pmid:24489868 30

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Dodle T, Mohanty D, Tripathy B, Panigrahy AB, Sirikonda S, Kumar L, et al
However, your metabolism will be even higher if you have a significant amount of muscle mass
It is a progressive condition