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Episodes occur when core body temperature regulation fails during sleep, causing perspiration severe enough to soak through clothing and beddingaffecting up to 41% of adults at some point

It is important to note that individual responses vary considerably

Over 80% of participants in both groups reported GI-related issues such as constipation, cramping, bloating, and diarrhoea

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5.2 Disorders of mitochondrial long-chain fatty acid oxidation 5.2.1 Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency Clinical presentation Patients diagnosed with VLCAD deficiency (OMIM 201475) can suffer from hepatic, cardiac and muscular symptoms that can appear in infancy, but also later during adolescence or adulthood