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Notably, while total FOXO4 protein levels remained consistent between young and elderly men, a striking age-dependent shift in its subcellular localization was observed: FOXO4 predominantly resided in the cytoplasm in young Leydig cells but translocated to the nucleus in aged cells

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In male rats, a HFD (G0-P21) reduced POS-induced cognitive impairments as measured in the MWM at M4-7 [137] and the conditioned odor preference (COP) at M6 [141]

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NMSC treatment depends on the type of cancer

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