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Therefore, these approaches may not fully reflect the chronic, low-level environmental exposures typically experienced by women [100]

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Table 3 : Incidence of Overall a and Severe b Hypoglycemic Events in Placebo-Controlled Clinical Trials for Glycemic Control in Adults with Type 2 Diabetes Mellitus c Other Adverse Reactions In Clinical Trials With Empagliflozin In Adults Genital Mycotic Infections: In the pool of five placebo-controlled clinical trials, the incidence of genital mycotic infections (e.g., vaginal mycotic infection, vaginal infection, genital infection fungal, vulvovaginal candidiasis, and vulvitis) was increased in patients treated with empagliflozin compared to placebo, occurring in 0.9%, 4.1%, and 3.7% of patients randomized to placebo, empagliflozin 10 mg, and empagliflozin 25 mg, respectively

At steady state, average blood levels are higher and more stable than after the first dose, which often translates into smoother appetite and glucose effectsand sometimes more noticeable GI side effects during dose increases

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