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Causes of obstruction leading to portal hypertension are classified by site: (1) presinusoidal, (2) sinusoidal, and (3) postsinusoidal

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PMID 27053679

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Mast cells are present adjacent to the neurons and glial cells in thalamus, hypothalamus, and leptomeninges and activate them by cell-to-cell contacts as well as by releasing inflammatory and neurotoxic mediators (Theoharides et al., 2013)