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Absorption through the gut depends on a protein called intrinsic factor, production of which declines with age, certain medications (notably metformin and proton-pump inhibitors), and conditions such as atrophic gastritis

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AHAs and BHAs: The Over-Exfoliation Problem Alpha hydroxy acids (like glycolic and lactic acid) and beta hydroxy acids (like salicylic acid) are among the most problematic ingredients to mix with retinol, yet theyre commonly combined by well-meaning users

Other Precautions: Long-term use may reduce zinc levels