GPX5 is an unusual member of the mammalian GPX family because, unlike the well-known mammalian GPX1-4, it does not contain selenosylcysteine (Secys) at its active site, but instead has cysteine residues (Cys) as its active site (Taylor et al., 2013)
Bassi S, Ferrarese C, Finoia MG, and et al
Thus, studies suggest that PQQ may be beneficial in insulin resistance and type 2 diabetes ( in vivo and in vitro , regulated by the NLRP3 inflammasome ( PQQ showed protective effects on lipotoxicity and inflammation caused by maternal obesity, and intervention on the risk of NAFLD ( 8 PQQ with other drugs Statins are antihyperlipidemic drugs prescribed to those at high risk of cardiovascular disease
Some supplements, such as berberine, fiber, omega-3s, probiotics, and curcumin, may offer mild metabolic support, but they do not work like prescription GLP-1 drugs and should not be presented as substitutes (Reference)
Since ADA (American Diabetes Association) and FDA confirmed that apart from metformin in Type 2 diabetes management, Glucagon-like peptide-1 analogues give favourable results, especially in contraindication and metformin intolerance patients, so the use of GLP-1 agonists is highly preferred treatment in lower serum glucose levels or hypoglycemia
Dizziness and fatigue may accompany headaches in some patients
