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1 Despite these constraints, the commercial consequence has been significant: Medicare logged $27.5 billion in gross GLP-1 spending across 21.8 million claims in 2024, entirely under FDA-approved indications other than obesity

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Mounjaro is FDA-approved for managing type 2 diabetes, while Zepbound is approved for chronic weight control

In particular, AI-based models could help link in vivo OCT featuressuch as HRFwith microglial activation observed in animal models or post-mortem human tissue, thereby helping to exclude alternative explanations for the origin of hyperreflective signals on OCT