Extensive evidence highlights its key safety characteristics: No genotoxic or mutagenic activity: The JofEM study [2] on AOD 9604 reported no genotoxic effects in rats and cynomolgus monkeys during Ames, chromosomal aberration, and bone micronucleus assays
Besides GSH and H 2 S, cysteine is converted to the sulfur containing molecule taurine by the action of the enzyme cysteine dioxygenase (CDO) to form cysteinesulfinic acid, which can then be decarboxylated to hypotaurine by cysteinesulfinic acid decarboxylase, and the hypotaurine generated, oxidized to taurine (Stipanuk and Ueki, 2011) (Figure 1)
As a substrate for glutathione S-transferase (GST), this agent reacts with many of harmful chemical such as halides, epoxides and free radicals to form harmless inactive products [1]
This reduced level of levocarnitine results in decreased energy, leading to muscle weakness
The extensive intracellular network of cell death-regulating factors implies an elaborate and refined multi-level regulation of cell death signaling
By blocking NNMT activity, it has been investigated for its influence on cellular metabolism
