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Lots of research suggests such medications must be used indefinitely to maintain weight loss and related health benefits

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The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia

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68 , 404417 (2012) Emsley, P., Lohkamp, B., Scott, W

There is strong evidence that GLP-1 medications can: Improve HbA1c and blood glucose control Support appetite regulation Improve cardiovascular risk markers in some populations Support improvements in cholesterol and triglycerides Lower blood pressure (modestly) Reduce risk of major cardiovascular events in higher-risk individuals For many people, these changes occur independently of weight reduction and are linked to improved metabolic functioning