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140 For people with obstructive sleep apnea who continue to suffer from excessive daytime sleepiness despite CPAP therapy, modafinil (or armodafinil) can reduce daytime sleepiness and improve wakefulness

The proposed mechanisms are delayed gastric emptying through brain and enteric CB 1 receptor stimulation, thermoregulatory disturbances via the limbic system, or CB 1 receptor-mediated vasodilatation of the splanchnic bed [17, 18]

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For very long-term protocols (months), more full assessments every 2-3 months may be warranted

Special issue: non-pharmacological interventions for people with Parkinsons disease: are we entering a new era

References 1 CampbellJEDruckerDD