Preclinical data support a positive effect of NAC on cognition in animal models of mitochondrial dysfunction, inherited metabolic disorders, heavy metal neurotoxicity, and Alzheimers disease [101-105]
In a recent in vivo/ex vivo study using a rat model of ischemic stroke induced by MCAO, systemic administration of exendin-4 was found to be neuroprotective via its vasodilatory action on cortical arterioles and improved CBF [69]
Patients should contact their healthcare provider immediately if they experience severe abdominal pain (which may indicate pancreatitis), persistent vomiting leading to dehydration, changes in vision (particularly in patients with diabetes or existing retinopathy), symptoms of thyroid tumors (neck mass, difficulty swallowing, persistent hoarseness), signs of gallbladder disease , or serious allergic reactions (rash, itching, rapid heartbeat, trouble breathing)
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BAX, Bcl-2-associated X Protein