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Another study by Liao et al

In an experimental model of abdominal aortic aneurysm, topiramate markedly downregulated pro-inflammatory M1 macrophage activity, reduced the expression of TNF-, IL-1, and matrix metalloproteinase-9, and promoted a phenotypic shift of macrophages from M1 to M2, thereby mitigating pro-inflammatory activity and enhancing tissue repair processes ( These studies collectively suggest that topiramate exerts significant neuroprotective effects across various pathological models through its potent anti-inflammatory properties

It has been shown that the level of MDA increases whereas superoxide dismutase and GPx decreases in stored blood and therefore supplementation with antioxidants and vitamins is needs prior to blood transfusion (Marjani et al ., 2007)

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Increased fat burning during exercise continues even during the recovery phase