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doi: 10.3346/jkms.2019.34.e224 23 ChenQLiuTZhouHPengHYanC

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Researchers working with this compound should remain mindful of the important scientific context outlined in this guide: no specific receptor has been conclusively identified, the evidence base varies in strength across the documented mechanisms, and the majority of published research derives from animal models with a significant proportion from a single research group

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In the technical scheme of the invention, the condensing agent adopted in the coupling in the step (3) and the step (5) comprises DIC + A or B + A + C, wherein A is HOBt or HOAt, B is HBTU, HATU or PyBOP, and C is DIEA or TMP or DMAP