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10 A conservative, well-chosen dose is needed to support systemic levels without overwhelming physiologic balance

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T2DM is the most common type of diabetes mellitus, accounting for 9095 percent of cases, and is characterized by insulin resistance and/or -cell dysfunction (229, 230)

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The subcutaneous injection introduces a small volume of solution into the tissue beneath the skin, which can cause mechanical tissue distension and activate local nociceptors