For quantification of severity and staining scores, two experienced scientists carried out a histological evaluation of 4 images per mouse at 2 magnifications, independently and in a blinded manner
#FDAApproval #GLP1 #Obesity #MetabolicHealth #OralTherapies #PharmaInnovation #ClinicalDevelopment #PatientCentricity #NovoNordisk #WeightManagement #HealthcareTransformation To view or add a comment, sign in The oral GLP-1 era has officially begun
But here's the scientific reality: that's a massive oversimplification
Widlund HR, Horstmann MA, Price ER, Cui J, Lessnick SL, Wu M et al
Efficacy analyses were performed on two sets: the full analysis set, defined as all unique randomized patients grouped according to the treatment assigned at randomization, thereby following the intent-to-treat principle, and an on-treatment analysis, defined as all exposed patients while they were receiving treatment (that is, had received at least one dose in the previous 35 d), grouped according to the treatment that they received
Two synthetic OXTR agonists, TC-OT-39 and carbetocin, and the metabolite [Cyt6]OT(59), did not increase the duration of social interaction in the BALB/cByJ mice
