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One of the most critical aspects of senescence is the senescence-associated secretory phenotype (SASP)

I., Marino, F., & Cosentino, M

Animal and human studies have demonstrated these effects, making it a potential therapeutic for conditions related to sexual function

These effects typically emerge during dose initiation or escalation and often diminish over time as the body adjusts to the medication

However, these L-NAME effects would not affect the stomach lesions presentation likely because of the process of overlapping cytoprotection/adaptive cytoprotection that was immediately initiated

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