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In contrast, metformin did not cause significant changes in any of the metabolic parameters under analysis (Fig

and IFN- by blocking intracellular signaling of pro-inflammatory factors such as IL-6, IL-12, IL-23, and IFN- [397], significantly improved Disease Activity Score (DAS28-CRP), HAQ-DI, and patient-reported pain, dysfunction, and ruxolitinib demonstrated significant improvement in fatigue symptoms in Phase III RA clinical trials, including the RA-BEAM and RA-BUILD studies [398, 399], furthermore, in a Phase IIb clinical trial, ruxolitinib demonstrated significant efficacy in plaque psoriasis treatment, as evidenced by improved Psoriasis Area and Severity Index 75 response rates [399]

Fiber supplements, such as psyllium, can also be helpful when food intake is limited

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