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There already have been notable disappointments and claims that the drugs caused serious side effects

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Further, while GLP-1RAs have a positive impact on the LVEF, it seems to be inconsistent in most patients with heart failure and effects are quite limited [174]

Stability is primarily provided by a complex network of soft tissues: the rotator cuff muscles and their tendons, the labrum (a cartilaginous ring that deepens the socket), and various ligaments