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Large clinical trials study these medications at the doses approved or under evaluation by the FDA
Against Naltrexone/Bupropion, observed associations with reduced incidence emerged for cataracts (HR 0.37, 95% CI: 0.180.75, p = 0.004), oculomotor binocular dysfunction (HR 0.46, 95% CI: 0.270.79, p = 0.004), dry eye disease (HR 0.36, 95% CI: 0.180.73, p = 0.003), and ametropic accommodative dysfunction (HR 0.50, 95% CI: 0.290.87, p = 0.012)
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Until retatrutide has equivalent data, semaglutide is the evidence-based choice for people with established heart disease