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Additionally, improvements in fibrosis may not directly translate to immediate clinical benefits, complicating the assessment of treatment efficacy

However, limited lifestyle guidance and unresponsive communication hold it back

Naloxone (Narcan), naltrexone (Trexan

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The 12:12 approach still produces metabolic benefits

This work was supported by the Funds of National Natural Science Foundation of China (82060728), Guizhou Provincial Science and Technology Department (MS [2025-380], Thousand Talents Program), Talents of Guizhou Science and Technology Platform [2021]1350-009, Zunyi Science and Technology Bureau (HZ-2023-173, HZ-2023-09, [2024] No