Transporter Endogenous Substrates References MRP1 GSH conjugates, cysteinyl leukotrienes, glucuronic acid conjugates, bilirubin, estradiol, sulfate conjugates, bile salts, sulfated steroids, GSH, GSSG [82,107,108] MRP2 GSH conjugates, cysteinyl leukotrienes, glucuronic acid conjugates, bilirubin, estradiol, sulfate conjugates, bile salts, sulfated steroids, GSH, GSSG [82,107,109,110] MRP3 GSH conjugates, cysteinyl leukotrienes, glucuronic acid conjugates, bilirubin, estradiol, sulfate conjugates, bile salts [82,107,111] MRP4 GSH conjugates, cysteinyl leukotrienes, glucuronic acid conjugates, estradiol, sulfate conjugates, sulfate conjugates, cyclic nucleotides, bile salts [82,111113] MRP5 GSH conjugates, glucuronic acid conjugates, cyclic nucleotides, GSH [82,111,114] MRP6 GSH conjugates, cysteinyl leukotrienes [82,115] MRP7 GSH conjugates, cysteinyl leukotrienes, glucuronic acid conjugates, estradiol [82,116] MRP8 GSH conjugates, cysteinyl leukotrienes, glucuronic acid conjugates, estradiol, sulfate conjugates, cyclic nucleotides, GSH [82,116] MRP9 Unknown, but not drug conjugates or other organic anions [117] 4.2

Replicates, randomization and blinding In vivo studies were performed in male mice that were randomly distributed in groups matched for genotype, age, body weight and body composition (fat and lean tissue mass)
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1992 Nov;120(5):720-5
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Sarcopenia associated with chronic obstructive pulmonary disease