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GLP-1 is a gut hormone released after eating that signals the brain to reduce appetite, slows gastric emptying (so you feel fuller longer), stimulates insulin release from the pancreas, and suppresses glucagon (which would otherwise raise blood sugar)

0.93% in those on placebo at 68 weeks 73

However, patients should seek urgent medical evaluation for severe or persistent abdominal pain (especially in the right upper quadrant), vomiting, fever, jaundice, or symptoms suggestive of pancreatitis

Wegovy Dig deeper: Zepbound and Wegovy are both GLP-1 drugs approved for weight loss, but Zepbound targets two hormones, GIP and GLP-1, while Wegovy only targets GLP-1

Currently, some health plans are seeing spending on the drugs rise 40% to 50% annually, according to the spokesperson

At this point, the focus shifts from active weight loss to weight maintenance, which the medication continues to support through appetite suppression and metabolic effects