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It can serve as an alternative delivery method, but it is not a direct replacement

Hypertonic saline could osmotically pull fluid into the intravascular space, thereby promoting diuresis without intravascular volume depletion

Animal studies have raised concerns including smaller fetuses, delayed bone development, skeletal changes and pregnancy loss, especially when mothers lose a significant amount of weight during early fetal development

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In long-term extension studies, catheter sepsis was reported in 28% a hazard of the underlying condition and its central line rather than of the drug itself [4]

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