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doi: 10.1086/432579

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These targets are saturated among major players - you need an angle that solves key issues existing "anchor programs" will face: Muscle preservation (ex: Lilly / Versanis - $1.9B) Combo synergies (ex: Novo / Lexicon - $1B) Oral treatments (ex: Novo / Septerna - $2.2B) Completely novel MoAs (ex: Novo / Inversago - $1.1B) A few major Pharma remain largely on the sidelines (JNJ, BMS, Novartis, Sanofi) and might take a bet on a late-stage anchor asset, but (a) mgmt