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Microplastics cause changes in protein structure [2], interact with cell membrane lipids, induce transcription of inflammatory genes and increase production of pro-inflammatory cytokines, lead to dysfunction of the endoplasmic reticulum, mitochondria and induce cell death due to oxidative stress

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In 1970, James Bartley and Roger Chalkley showed that histones of calf thymus nucleohistone are protease resistant when complexed with DNA, whereas when freed from DNA, they rapidly degraded, indicating the presence of DNA-binding-induced structure (Doolittle, 1973)

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