Future studies should adopt targeted designs to mitigate these issues: Confounding by coexisting nutrient deficiencies: mineral deficiencies [e.g., zinc (344)] or vitamin deficiencies [e.g., vitamin D (169, 347349)] often co-occur with protein or fiber deficiencies
For instance, antioxidant therapy alone may not be suitable for all pathological stages and could obscure its potential double-edged sword effects
Taking supplements in the morning also aligns with the bodys natural circadian rhythms and energy production cycles
& Henry, R
Dont chug, sip steadily throughout the day
Their evidence base comes from trial programs such as STEP (semaglutide for weight management, published in The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)