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In a commentary on this new study, Carsten Dirksen and Sten Madsbad remind us of the need for more data to guide clinical recommendations

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We hypothesized that a class of drugs known as GLP-1R agonists, which have anti-inflammatory effects and suppress muscle wasting, could be beneficial in this context. To test this, the researchers first determined whether the GLP-1R is expressed on muscle fibers affected in PM by analyzing muscle specimens from patients with PM as well as a mouse model of PM

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Rapamycin, not metformin, mirrors dietary restriction-driven lifespan extension in vertebrates: a meta-analysis