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Taken together, these findings indicated that hepsin / mice experience heightened oxidative stress in the early stages of APAP exposure, suggesting that endogenous hepsin might protect against toxicity during the early stages of APAP exposure, thereby significantly influencing survival outcomes in drug-induced toxicity cases

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GSH and similar antioxidant enzymes are lower in the blood of patients with MDD compared to controls, suggesting that there is an effect of GSH in the pathology of MDD (Maes et al