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The E-values were notably high, at 4.51 for all-cause mortality, 2.38 for MACEs, and 2.00 for MAKEs, indicating that the observed associations are unlikely to be explained away by potential confounding (Supplemental Table 7)

Typically, this is done once a week

Zagare A, Kurlovics J, Almeida C, Ferrante D, Frangenberg D, Vitali A, Gomez-Giro G, Jger C, Antony P, Halder R, Krger R, Glaab E, Stalidzans E, Arena G, Schwamborn JC (2025b) Insulin resistance compromises midbrain organoid neuronal activity and metabolic efficiency predisposing to Parkinsons disease pathology

And frankly, the due diligence is so thin here that either were heading towards a disaster of unintended side effects, or we need to reconsider whether these drugs should require prescriptions at all." To view the full commentary from Dr F

Nat Genet 1996

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