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Furthermore, the C-terminus of Tesamorelin has been modified with a trans-3-hexenoic acid group

This phenomenon, known as the somatopause, is also seen in other mammals and has led to the speculation that GH treatment can be a potent anti-aging therapy (467)

Discussion In present study, we find that dysfunction of mitophagy may play an important role in pressure overload-induced cardiac hypertrophy, and semaglutide ameliorates this type of cardiac hypertrophy by improving mitophagy to suppress the activation of NLRP3 inflammasome

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