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Chemogenetic activation of GLP-1R neurons in the ARC, particularly neurons co-expressing POMC and GLP-1R in male mice, significantly suppressed feeding [86,87]
Journal of Research in Medical Sciences, 17 (12), 11611169
, Edwards, C
Splitting or Crushing: Why You Must Swallow the Tablet Whole While an effective barrier, the SNAC technology that protects oral GLP-1s is delicate
specifically examined patients with MASLD cirrhosis and type 2 diabetes, finding that GLP-1 receptor agonist initiation was linked to reduced risk of unfavorable liver outcomes including hepatic decompensation events and mortality from any cause (aHR: 0.78, 95%CI: 0.68-0.90) relative to non-users, suggesting potential benefits even in advanced liver disease populations [58]