Elagolix, (Figure 3), is a small molecule compound that is a first-in-class GnRH receptor antagonist approved for the treatment of moderate or severe pain associated with endometriosis [88,89]
Weiner BK, Vilendecic M, Ledic D, et al
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The investigators found that starting at a lower dose (2 mg rather than 4 mg) partially blunted the early gastrointestinal side effects the same titrate-slowly principle that governs approved incretin drugs
BouillonRMarcocciCCarmelietGBikleDWhiteJHDawson-HughesBet al