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Current clinical evidence for possible antidepressant effects of GLP-1R agonists Depression is often comorbid with metabolic disorders such as T2DM and obesity and many antidiabetic drugs, which often display neuroprotective and immunomodulatory effect, have demonstrated antidepressant properties in clinical trials

approval is not guaranteed based on the above criteria

In 2005, as flood waters from Hurricane Katrina rose and threatened his New Orleans home, John took an axe to his attic's ceiling, climbed atop his roof and tied himself to his chimney so he wouldn't be swept away

2021;18(3):e1003583

In December 2025, the FDA also expanded the Mounjaro indication to include paediatric patients aged ten and over with type 2 diabetes, following results from the SURPASS-PEDS trial

Table 1 Recent studies investigating GLP analogs and DPP-iv inhibitors use in inflammatory bowel disease