There was a black box warning about psychiatric side effects for years, but it was removed by the FDA after further research showed the risk was lower than initially thought
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HATs can introduce acetyl functional groups from acetyl donors (acetyl-CoA) into amino acid residues (including lysine), forming acetyl ester bonds and neutralizing their positive charges, leading to the relaxation of the nucleosome structure
The copper ion chelated to AHK-Cu can interact with free amino groups in other peptides, causing aggregation, precipitation, or dissociation of the copper complex
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Studies have found significant percentages of ergogenic supplements containing incorrect amino acid sequences or exceeding safe endotoxin thresholds