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Annals of Translational Medicine, 5 (16), 324
Because GHK-Cu copper peptide can be delivered intranasally, bypassing the restrictive blood-brain barrier, this route was selected as an efficient and non-invasive way to achieve central nervous system exposure
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Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed
The definition of vitamin B12 deficiency varies with the assay used but generally includes serum cobalamin levels below 148 pmol/L plus symptoms, or elevated serum homocysteine, or increased methylmalonic acid (MMA) (74)
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