She was initially started on topiramate, with significant improvement in her headache
Observational evidence further supports a context-dependent effect of metformin, as data from the National Alzheimers Coordinating Center database found that metformin use was associated with improved memory performance, but this benefit was not observed in APOE-4 carriers 90 , suggesting that metformin may be protective in individuals with DM2 but not in those with certain genetic predisposition factors for AD, such as APOE-4, which is the strongest genetic risk factor for sporadic AD 91
Focus on tracking your menstrual cycles to understand your new pattern, optimizing nutrition for pregnancy by increasing folate-rich foods and ensuring adequate protein, establishing an exercise routine if energy has returned, and addressing any nutrient deficiencies identified at your preconception visit
PMID: 29 American Diabetes Association Professional Practice Committee
Available at: Health Canada
A 6-month longitudinal study found that elevated cortisol, insulin resistance, and chronic stress levels were each linked to greater weight gain over time