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Voros C, Chatzinikolaou F, Papapanagiotou I, Polykalas S, Mavrogianni D, Koulakmanidis A-M, et al

Hackam DG, Peterson JC, and Spence JD (2000)

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In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist

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Gastrointestinal Issues: Nausea or stomach discomfort may occur in some cases