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Patients carrying specific variants may show superior response to dual-peptide therapy (tirzepatide) compared to single-peptide GLP-1 alone, without requiring additional appetite suppressants

Moreover, the more rapid reduction in weight due to caloric restriction on GLP-1 (semaglutide) or GLP-1/GIP (tirzepatide) can accelerate hormonal imbalance and heighten the risk of muscle wasting and the onset of osteoporosis

After recovering from this illness, many patients developed Parkinson's disease years later