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The reality is that that what the FDA means by safety is a matter of regulatory compliance (large scale clinical trials, manufacturing standards, etc.) not toxicity

No lethal dose has been identified across toxicology studies conducted to date

Of those, 93,615 (64 per cent) either had tests confirm they already had normal B12 levels, or they weren't tested at all

[27] Additionally, anyone with Lebers hereditary optic neuropathy (a rare inherited eye disease) must avoid cyanocobalamin injections, since B can precipitate rapid worsening of that condition

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Blended formulations allow researchers to evaluate interaction effects, signal amplification, and pathway modulation under controlled conditions