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Pressure was increased over a 15 to 60 min period to avoid a sharp change in temperature

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The pathophysiology of migraine is complex, and the role of genetic, metabolic, and hormonal factors has been proposed (195)

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A wide array of formulations or compositions of the compounds and formulations or compositions provided herein are contemplated as are a variety of treatments for any disease, disorder, or condition that would benefit by extended release administration of a therapeutic agent to the auris interna