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Early undernutrition induces glucagon resistance and insulin hypersensitivity in the liver of suckling rats

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Here, we document the efficacy of such unimolecular GLP1 multi-agonists, and particularly the superiority of the GLP1/E conjugate, in managing the metabolic complications of PCOS in two mouse models of the disease, with evidence also for improvement of reproductive traits in an ovulatory model of PCOS

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2f, M-CuP degraded rapidly, retaining about 58% and 50% after 0.5 and 4 h, respectively

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