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There is no official contraindication or documented drug-drug interaction between creatine supplementation and tirzepatide in the FDA-approved prescribing information or major drug interaction databases (Lexicomp, Micromedex)

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255,256,257 Liver-specific deletion of Lgr4 significantly restrains liver regeneration

doi: 10.1016/j.cmet.2021.04.004 35 BuchwaldHMenchacaHJMichalekVNRohdeTDHunninghakeDBO'DeaTJ

Hal tersebut terjadi karena glutathione menekan aktivitas enzim tirosinase yang berperan dalam pembentukan melanin, sehingga kadar melanin lebih rendah dan membuat kulit tampak cerah.

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