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2018 Moreover, 8-OHD markedly quenched reactive oxygen species (ROS) and activated NF-E2-related factor 2 (Nrf2) so as to upregulate expression of Phase II enzymes, including heme oxygenase (HO)-1, NADH quinone dehydrogenase 1 (NQO1), and the modifier subunit of glutamate cysteine ligase (GCLM)

This sensitivity is crucial, as it allows for detecting and quantifying GPx activity in samples containing low enzyme levels or limited amounts of substrates

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