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Nearly five decades later, that discovery remains a landmark in peptide neurobiology and also a case study in how much can remain unknown about a molecule despite sustained preclinical interest

Retinoids and their receptors in differentiation, embryogenesis, and neoplasia

[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Nakamoto F.K., Okamoto S., Mitsui J., Sone T., Ishikawa M., Yamamoto Y., Kanegae Y., Nakatake Y., Imaizumi K., Ishiura H., et al

This activation initiates a cascade of gene expression changes

B12 plays a key role in maintaining healthy nerve cells, producing red blood cells, and supporting DNA synthesis

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