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Knockdown of GLP-1 receptors in vagal afferents affects normal food intake and glycemia

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Liraglutide, semaglutide, and tirzepatide are all GLP-1 agonists resulting in significant weight loss in RCTs

As highlighted in a recent review, while GLP-1RAs show potential in treating SLE, further prospective investigations are needed to determine if they pose a risk of triggering autoimmune activity and whether their advantages in SLE outweigh such risks [292]

Since individual reference molecules exhibited a large number of features reflecting their distinct chemotypes direct merging into a single multi-ligand pharmacophore was not feasible