Long-term safety profiles in humans are unknown
At the level of functional intervention and therapeutic validation, multiple animal studies provide the most direct evidence
Inflammation and sensitivity often stem from a weakened skin barrier or chronic overstimulation, and finding solutions that truly help (without causing new issues) can feel overwhelming
In addition to the elevated blood pressure readings obtained from the sphygmomanometer, patients with hypertension often experience other issues such as endothelial dysfunction, increased peripheral vascular resistance, and arterial stiffness
Anyone with a personal or family cancer history should treat that as a hard stop
Likewise, many cuproproteins with redox, or redox-with-transport functions (mono-, di-, tetranuclear cupredoxins nitrite reductase, laccase, Cu, Zn-SOD1, amine oxidase CuAO, galactose oxidase, hemocyanin, tyrosinase, catechol oxidase, COX, N 2 O reductase, menaquinol NO reductase et cetera) [47], copper-transporting ATPases (Cu-ATPases, ATP7A and ATP7B) [124,125,126], divalent metal transporter DMT1 [127], copper transporters and chaperons Ctr1, Ctr2, Atox1 and CCS [128, 129], diverse group of bacterial periplasmic copper binding proteins (CopC) [130] are known